Why Your Brain Thinks You're Full (Even When You're Not)

How did the Gila monster, a desert lizard that eats just five times a year, help unlock the science behind Ozempic, Wegovy and Mounjaro?
In this episode of The Rest Is Science, Professor Hannah Fry and Michael Stevens (Vsauce) trace the strange journey from a molecule found in lizard venom to medicines reshaping diabetes and weight-loss treatment, exploring how GLP-1 helps regulate blood sugar, appetite and the hum of ‘food noise’.
Early evidence suggests their effects may extend far beyond food, quieting cravings for alcohol and cigarettes, and even the urge to gamble.
What might this reveal about the biology of wanting itself, and how much control do any of us really have over what we crave?
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Video Producer: Adam Thornton + Teo Ayodeji-Ansell + Jack Meek
Animator: Sam Benson
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Producer: Simona Rata
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Exec Producer: Neil Fearn

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